Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells
نویسندگان
چکیده
منابع مشابه
Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells.
TCR engagement triggers the polarized recruitment of membrane, actin, and transducer assemblies within the T cell-APC contact that amplify and specify signaling cascades and T effector activity. We report that caveolin-1, a scaffold that regulates polarity and signaling in nonlymphoid cells, is required for optimal TCR-induced actin polymerization, synaptic membrane raft polarity, and function ...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-09-672428